Contact lenses can cause a little discomfort initially. This discomfort usually goes away as you get used to wearing the lenses. Sometimes, the discomfort comes and goes, sometimes it only happens towards the end of the day. In this case, eye drops may be the solution. When you have your lenses on, you can’t just use any drops, you must use ones that come in single dose units, because they are preservative free. One of the most popular brands of dry eye drops that can be used with contact lenses is Cellufresh, which is available at most pharmacies, without prescription. You can insert the drops whenever your eyes feel uncomfortable, you don’t have to stick to a specific schedule.